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filingDate 2011-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80cdecd63fc94b8bffde0c80fe8eca65
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publicationDate 2012-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2012055885-A
titleOfInvention Method for producing liposome by two-stage emulsification method using outer aqueous phase containing specific dispersant, method for producing liposome dispersion or dry powder thereof using the method for producing liposome, and liposome dispersion produced by the method Its dry powder
abstract Disclosed is an additive (dispersant) that can suppress leakage of liposomes such as encapsulated drugs from liposomes for long-term storage and can be used stably for a long period of time and a dry powder thereof. And a method for producing a liposome or liposome dispersion or a dry powder thereof by a two-stage emulsification method. In a secondary emulsification step, a dispersant that does not form a molecular aggregate by itself or a molecular aggregate by itself that has a volume average particle size of 10 nm or less (hereinafter referred to as “specific dispersant”). A method for producing liposomes by a two-stage emulsification method, and a method for producing a liposome dispersion and a dry powder thereof using the production method. As the specific dispersant, for example, it is preferable to contain at least one of gelatin, albumin, dextran or polyalkylene oxide compounds. [Selection figure] None
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021043045-A
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