| abstract |
An oil-in-water emulsified composition containing a poorly soluble drug at a high concentration, having good stability and suitable as an injection, and a method for producing the same. A water-soluble drug having a solubility in water of less than 1 mg / mL and a molecular weight of 500 or more, medium-chain fatty acid triglyceride in an amount of more than 80% by mass, and the total mass of the composition An oil component in an amount exceeding 6% by mass and a surfactant component containing a phospholipid in an amount of 50% by mass or more, and the oil-in-water containing a poorly soluble drug having an average particle size of the emulsified particles of less than 500 nm Type emulsified composition. [Selection figure] None |