http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012041360-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b21028b8670ca9390bdfcc9446a1395a |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7056 |
| filingDate | 2011-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bcb1490a6f8985fb2b265b6f5504b68d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_91a6b037f48e17f9359abd4f594daf8e |
| publicationDate | 2012-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2012041360-A |
| titleOfInvention | Novel lactam ring-opening enzyme and its use |
| abstract | An enzyme having an activity capable of reducing antibiotic activity (ie, toxicity) against eukaryotic cells without losing antibiotic activity against prokaryotic cells, and antibiotic activity against prokaryotic cells. A streptosricin derivative having reduced toxicity to eukaryotic cells while maintaining the above, a method for producing the same, and the like are provided. A protein having the amino acid sequence set forth in SEQ ID NO: 2, 4, 6, 8, 10, 12, 14 or 16 of the present invention is obtained by opening a streptococcal lactam to cause a streptococcal ring. Antibiotic activity against eukaryotic cells can be reduced without losing antibiotic activity against prokaryotic cells such as syn-D. Therefore, the above problems can be solved by using the protein of the present invention. [Selection figure] None |
| priorityDate | 2011-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 489.