| abstract |
The present invention provides a site-specific method for down-regulating the expression of connexin, which is a protein constituting a gap junction channel, which is a cell membrane structure that facilitates cell-cell communication, for therapeutic purposes and / or shaping purposes. A method comprising administering a formulation comprising at least one antisense polynucleotide to a connexin protein to a patient surface site or a patient body site where the regulation is required. The method is particularly useful in reducing neuronal cell death, wound healing, reduced inflammation, reduced scar formation, and skin rejuvenation and thickening. [Selection figure] None |