| abstract |
Disclosed is a small molecule non-peptide caspase inhibitor that potently and stably penetrates membranes resulting in effective inhibition of apoptosis in vivo. The present invention provides a compound of formula I, wherein R 1 is R 6 C (O) —, HC (O) —, R 6 SO 2 —, R 6 OC (O) —. , (R 6 ) 2 NC (O) —, (R 6 ) (H) NC (O) —, R 6 C (O) C (O) —, R 6 —, (R 6 ) 2 NC (O) C (O) -, R 6 (H) NC (O) C (O) - or R 6 OC (O) C ( O) - and it is; R 2 is hydrogen, -CF 3, - halo, -OR 7 , —NO 2 , —OCF 3 , —CN or R 8 ; R 3 is hydrogen or (C 1 -C 4) -aliphatic—; R 4 is —COOH or —COOR 8 ; R 5 is —CH 2 F or —CH 2 O-2,3,5,6-tetrafluorophenyl. [Selection figure] None |