| abstract |
An object of the present invention is to provide a needle-shaped composition for subcutaneous or transdermal administration, which contains a protein having physiological activity. An excipient selected from the group consisting of polylactic acid, hyaluronic acid, collagen, and poly (lactide-co-glycolide) in a supercritical or subcritical carbon dioxide gas, and a protein having physiological activity. A method for producing a composition, which comprises melting to form a homogeneous mixture, and then solidifying the mixture into a needle shape. [Selection] Figure 1 |