| abstract |
Disclosed is a novel compound capable of cooperatively inhibiting ectoenzymes dipeptidyl peptidase IV (DPIV) and alanylaminopeptidase N (APN). Acid addition salts with compounds of formula (I) or organic and / or inorganic acids. [Wherein the residues R1, R2, R3 and R4 may be the same or different and are —H,> C (═O), —C (═O) O—, etc., and E is —O— , -S-, -NH-, etc., Y is -O-, -NH-, etc., B is an alkyl or alkoxy substituent having an aryl group or heterocycle, and C is an amide A substituent having a bond or a sulfonamide bond. ] [Selection figure] None |