| abstract |
The present invention provides novel compounds and pharmaceutically acceptable derivatives thereof that are useful as caspase inhibitors. These compounds are represented by the general formula (I): [Chemical 1] Wherein R 1 , R 2 and R 3 are as described herein, the A ring contains 0 to 2 double bonds, and each X is independently nitrogen Or selected from carbon, wherein at least one X in the A ring is nitrogen, ring A is optionally substituted as described, and is saturated or unsaturated, 0-3 heteroatoms. Provided that when X 3 is carbon, the substituent on X 3 is an atom other than nitrogen. [Selection figure] None |