| abstract |
Useful small interfering RNA vectors for the treatment of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, spinocerebellar ataxia type 1, type 2, type 3, and / or dentate nucleus red nucleus And providing a method. The step of surgically implanting a catheter such that the discharge portion of the catheter is located adjacent to a predetermined infusion portion in the brain and the production of at least one neurodegenerative disease protein can be inhibited. An apparatus for treating a neurodegenerative disease comprising the step of releasing at least one substance through a release portion of a catheter, a predetermined dosage. The device delivers small interfering RNA in the form of DNA encoding the small interfering RNA directly to the brain target cells using a viral vector. [Selection figure] None |