| abstract |
The present invention is designed to modify specific genes expressed in the targeted cells, and not only epidermolysis bullosa, cystic fibrosis, congenital nail thickening, and psoriasis or neurodermatitis as well as the skin Relates to a specific and markedly improved pre-mRNA trans-splicing molecule (RTM) molecule associated with various cancers. Specifically, the RTMs of the present invention provide specific target pre-expressed in the targeted cells so that correction of the gene defect or reprogramming of gene expression responsible for a variety of different skin disorders is obtained. -Gene engineered to interact with mRNA. |