http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011525900-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C279-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C277-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-08 |
| filingDate | 2008-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2011525900-A |
| titleOfInvention | A novel metformin salt of glycinate for blood glucose control |
| abstract | In the present invention, a novel 1,1-dimethylbiguanide glycinate salt called metformin glycinate was synthesized. This salt has advantages over other metformin salts. These advantages are primarily due to the fact that the glycine counterion itself exhibits a hypoglycemic effect. Moreover, this salt absorbs faster and reaches higher plasma concentrations than those produced with metformin hydrochloride. The synthesis is performed from metformin hydrochloride salt, in which free metformin is produced by releasing the counter ion of the hydrochloride using an ion exchange column, and the released metformin base is dissolved in an aqueous medium followed by ambient Glycine is added with continuous stirring at temperature, and the resulting product is then heated until a concentrated solution is formed, which makes the glycine insoluble in the medium and favors crystallization of the saturated medium. In addition, an organic solvent in which glycine is insoluble and does not react with the components present is added. This is all for precipitating excess glycine and separating the precipitate by filtration. The filtrate was then concentrated again until precipitation of metformin glycinate was achieved. [Selection] Figure 7 |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7005071-B1 |
| priorityDate | 2008-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 127.