| abstract |
Provided are a polyglycol-modified chitosan oligosaccharide fatty acid grafted product having a structural unit of formula (I) and a structural unit of formula (II), and a preparation method thereof, wherein the molecular weight of the chitosan oligosaccharide is 200 Less than 1,000, the degree of deacetylation is 70% to 100%, a part of free amino on the chitosan oligosaccharide chain is substituted with fatty acid or polyglycol, n is the degree of polymerization of polyglycol, R Is an alkyl having 11 to 21 carbon atoms, the grafting rate of fatty acid is 1% to 50%, and the grafting rate of polyglycol is 0.05% to 50%. Further provided are pharmaceutical compositions comprising a chitosan oligosaccharide fatty acid graft modified with polyglycol as a carrier, and the use of the chitosan oligosaccharide fatty acid graft modified with polyglycol in the manufacture of the pharmaceutical composition. [Selection figure] None |