| abstract |
The present invention relates to novel compounds of formulas (I), (Il), (Iu 1-20 ), (Iv 1-20 ), (Iw 1-20 ), (Ix 1-7 ), their pharmaceutically acceptable compounds. The possible salts and pharmaceutical compositions thereof are useful for therapeutic treatment of diseases associated with modulation or inhibition of 11β-HSD1 in mammals. The present invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in reducing or controlling cortisol production in cells or inhibiting the conversion of cortisone to cortisol in cells. |