| abstract |
The present invention relates to a method for producing a composition rich in IgA (S-IgA) by fractionating milk containing S-IgA. Such compositions are particularly useful in treating and / or preventing infection and / or inflammation of mucosal surfaces (eg, gastrointestinal tract, urogenital tract, airways, nasal cavity or oral cavity) in subjects in need of treatment, obesity And can be used for the treatment and / or prevention of diseases associated therewith, or the treatment and / or prevention of food allergies. Briefly, the present invention provides a method for producing a secreted immunoglobulin A rich milk fraction using one or more microporous membrane filtration steps. A preferred protocol for the method of the present invention includes the steps of degreasing, microfiltration and ultrafiltration-concentration through multiple diafiltration cycles. In addition to being able to achieve unexpectedly high yields, the method of the present invention has applicability, application in current diary factories, and controllability of process parameters affecting S-IgA quality and stability. Provides particularly interesting benefits in terms of [Selection figure] None |