| abstract |
Many fluoroquinolones can cause turbidity when used in pharmaceutical solutions, particularly viscous aqueous solutions (eg, aqueous ophthalmic multi-dose solutions). As a further example, many fluoroquinolones, especially hydrophobic fluoroquinolones, tend to exhibit lower bioavailability in such solutions. Disclosed herein is a pharmaceutical composition comprising a fluoroquinolone antibiotic. The composition exhibits improved homogeneity, improved bioavailability, lower turbidity or a combination thereof. The composition can be used as an otic or nasal composition, but is particularly useful as an ophthalmic composition. |