| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-782 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-606
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-553
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-49
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-4906 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-661
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7076
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-395 |
| filingDate |
2008-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2011-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2011520872-A |
| titleOfInvention |
A composition for regulating cellular senescence comprising an inhibitor of lysophosphatidic acid and adenylyl cyclase as active ingredients |
| abstract |
The present invention relates to a molecular mechanism for inducing cell proliferation of aged human fibroblasts by inhibiting AMPK in human fibroblasts by LPA and AC inhibitor. More specifically, the present invention is a composition containing LPA and ACI as active ingredients, and LPA and ACI regulate the phosphorylation of AMPKα differently, thereby inactivating p53 and inducing senescent cell proliferation phenomenon These results proved that AMPK signaling has an important effect on the senescent cell proliferation phenomenon. [Selection figure] None |
| priorityDate |
2008-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |