| abstract |
Embodiments of the present invention include particles having nucleic acid complexes, medical devices including the same, and related methods. In one embodiment, the present invention may include a method for manufacturing a medical device. The method comprises contacting a nucleic acid with a cationic carrier agent to form a nucleic acid complex, adsorbing the nucleic acid complex to porous particles to form a nucleic acid complex containing particles, and a nucleic acid complex containing particles Can be mixed with the polymer solution to form a coating mixture, and the coating mixture can be applied to the substrate. In one embodiment, the method comprises contacting a nucleic acid with a cationic carrier agent to form a nucleic acid complex, combining the nucleic acid complex with a material to form a nucleic acid complex containing particles in situ, Mixing the body particles with the polymer solution to form a coating mixture and applying the coating mixture to a substrate. In one embodiment, the present invention comprises a substrate, an elution control matrix disposed on the substrate, a plurality of particles disposed within the elution control matrix, and a plurality of nucleic acid complexes disposed within the particles. And an implantable medical device, wherein the nucleic acid complex comprises a nucleic acid and a cationic carrier agent. Other embodiments are also included herein. [Selection] Figure 1 |