| abstract |
The following peptides and their derivatives of general formula (I): H 2 N- GHRPX 1 X 2 PX 3 X 4 X 5 PX 6 PPPX 7 X 8 X 9 X 10 B (1) B (2) B (3) - X 11 [wherein B (1) represents either a chemical bond or amino acid G, B (2) represents either a chemical bond or amino acid Y, and B (3) represents a chemical bond or amino acid. Any one of R, X 1 -X 10 represents one of the 20 amino acids encoded by the gene, X 11 is OR 1 (R 1 = hydrogen or (C 1 -C 10 alkyl)), or NR 2 R 3 (R 2 and R 3 are the same or different, hydrogen, (C 1 ~C 10) alkyl or a residue -PEG 5-60K (wherein, PEG residues N atom via a spacer, bound represents a by and)), or a residue NH-Y-Z-PEG 5-60K ( wherein a, Y is the chemical Or Z represents a spacer by which polyethylene glycol (PEG) residues can be bound)] or their physiological Acceptable salt. |