| abstract |
Compound of formula 2; compound of formula 3; alkaline earth metal hydroxide of formula 4 (M is Ca, Sr or Ba), alkali metal carbonate of formula 4a (M 1 is Li, Na or K) At least one compound selected from the group consisting of 1,5-diazabicyclo [4.3.0] non-5-ene and 1,8-diazabicyclo [5.4.0] undec-7-ene. A compound of formula 1 (Q and Z as defined in this disclosure) comprising distilling off water from a mixture comprising a base; and an aprotic solvent capable of forming a low boiling azeotrope with water. As described above). [Chemical 1] (1) A reaction mixture containing a Grignard reagent derived from a step of contacting a compound of formula 5 (X is Cl, Br or I) with metal magnesium or an alkylmagnesium halide in the presence of an ether solvent. The step of forming, then (2) the reaction mixture is a compound of formula 6 wherein Y is OR 11 or NR 12 R 13 and R 11 , R 12 and R 13 are as defined in this disclosure. There is also disclosed a process for preparing a compound of formula 2 comprising the step of contacting with [Chemical 2] A compound of formula 7 using a compound of formula 1 further comprising preparing a compound of formula 1 by the method disclosed above or using a compound of formula 1 prepared by the method disclosed above A method of preparation (Q and Z are as defined in this disclosure) is disclosed. [Chemical 3] |