| abstract |
Compounds of formula (IA) or (IB) are IKK inhibitors useful in the treatment of autoimmune and inflammatory diseases: [Wherein R 7 is hydrogen or optionally substituted (C 1 -C 6 ) alkyl; A is optionally substituted aryl or heteroaryl of 5 to 13 ring atoms; Yes; Z is the formula R 1 C (R 2 ) (R 3 ) NH—YL 1 —X 1 — (CH 2 ) z — (where R 1 is a carboxylic acid group (—COOH), or one or more cells An ester group that is hydrolyzed to a carboxylic acid group by an internal esterase enzyme; and R 2 and R 3 independently denote the side chain of a natural or non-natural α-amino acid, either R 2 or R 3 Are not hydrogen or R 2 and R 3 together with the carbon atom to which they are attached form a C 3 to C 7 cycloalkyl ring, z, Y, L 1 and X 1 are claimed As defined in the scope of [Selection figure] None |