http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011517949-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 |
| filingDate | 2009-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2011517949-A |
| titleOfInvention | In vitro estimation of in vivo half-life binding proteins |
| abstract | The present invention discloses a method used to estimate the in vivo half-life of a binding protein of interest. The disclosed method comprises (a) determining an in vitro half-life for a binding protein of interest and for at least two different reference binding proteins using an in vitro protease reaction assay, wherein the reference binding proteins are known different Having an in vivo half-life), (b) determining a correlation between a known in vivo half-life and an in vitro proteolytic half-life for each of the reference binding proteins, and (c) a known in vivo half-life for the reference binding protein Estimating from the correlation between the in vitro proteolytic half-life the in vivo half-life of the binding protein of interest correlated with the in vitro proteolytic half-life of the binding protein of interest. |
| priorityDate | 2008-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 99.