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filingDate 2009-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2011-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2011516497-A
titleOfInvention Treatment of bladder dysfunction using liposomal botulinum toxin
abstract Liposomes are used for intravesical drug delivery to help improve lower urinary tract symptoms by reducing bladder irritation and frequency, specifically for delivery of botulinum toxin (BoNT). This system uses a lower and safer dose of BoNT and has a lower risk of urinary retention. A simple instillation of liposome-BoNT (typically 30-60 ml) as a liquid formulation into the bladder provides an efficacy similar to that currently achieved using cystoscopic needle injection of BoNT. Will be achieved. The dose can be lower than that obtained by injection, thereby significantly reducing the risk of urinary retention. Liposome-BoNT can protect BoNT from degradation in the bladder and urine. Liposome-BoNT instillation is more familiar to cystoscopic BoNT injection and is more comfortable for the patient than another method restricted to certified physicians, providing this form of treatment to more clinics It is possible.
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