| abstract |
The present invention provides a composition comprising a nucleic acid that targets CSN5 gene expression, and methods of using the composition to silence CSN5 gene expression. More specifically, the present invention relates to unmodified and chemically modified interfering RNA molecules that silence CSN5 gene expression, and methods of use thereof, such as methods of treating cell proliferation disorders such as cancer. provide. The invention also provides nucleic acid-lipid particles targeting CSN5 gene expression comprising interfering RNA molecules, cationic lipids, non-cationic lipids, and optionally complex lipids that inhibit particle aggregation. |