| abstract |
The present invention provides methods for treating or preventing colorectal cancer using, for example, anti-IGF1R antibodies with sunitinib or with a combination of leucovorin and 5-fluorouracil. In one embodiment, a method for treating or preventing colorectal cancer in a subject is provided, the method comprising a therapeutically effective amount of an isolated antibody or leucovorin and 5-fluorouracil or with sunitinib Administering the antigen-binding fragment thereof, wherein the isolated antibody or antigen-binding fragment thereof comprises: (a) a CDR- of the variable region of light chain C, light chain D, light chain E or light chain F; L1, CDR-L2 and CDR-L3; or (b) the group consisting of CDR-H1, CDR-H2 and CDR-H3 of the variable region of heavy chain A or heavy chain B; or those It includes one or more members selected from the group consisting of both. |