http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011515444-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1641 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 |
| filingDate | 2009-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2011515444-A |
| titleOfInvention | Method for preparing solid dispersion |
| abstract | A method for preparing a solid dispersion of a polyvinyl alcohol-polyethylene glycol graft copolymer (PVA-PEG graft copolymer) such as Kollicoat IR, comprising a BCS class II drug or a BCS class IV drug, and a) polyvinyl alcohol A step of separately dissolving a polyethylene glycol graft copolymer (PVA-PEG graft copolymer) in a water / primary alcohol mixture, and b) a BCS class II drug or a BCS class IV drug with high solubility of the compound. A step of dissolving in a mixture of a non-alcoholic organic solvent and a second alcohol, and c) mixing both of the above solutions so that the total amount of dissolved solids is 1 to 15 g per 100 ml, and if necessary, In order for the mixture of both solutions to obtain an acidic pH, a solution such as hydrochloric acid or hydrobromic acid is used. Inorganic acids such as hydrogenic acid, sulfuric acid, nitric acid, phosphoric acid, or acetic acid, propanoic acid, hydroxyacetic acid, lactic acid, pyruvic acid, succinic acid, malonic acid, succinic acid, maleic acid, fumaric acid, malic acid, tartaric acid, Acids such as citric acid, methane sulfonic acid, ethane sulfonic acid, benzene sulfonic acid, p-toluene sulfonic acid, cyclamic acid, salicylic acid, p-amino salicylic acid, palmic acid, etc. are added to the mixture of each of the above solutions. And a step of spray-drying the third solution. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020509032-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018507896-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9511026-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017500349-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012527491-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10596118-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7218294-B2 |
| priorityDate | 2008-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 655.