http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011514334-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-108 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 |
| filingDate | 2009-02-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2011514334-A |
| titleOfInvention | Methods for preparing pharmaceutical formulations of contrast agents |
| abstract | The present invention relates to a complex of a macrocyclic chelate compound and a lanthanide, between 0.002% and 0.4%, preferably between 0.02% and 0.3%, very preferably from 0.002%. The present invention relates to a method for preparing a liquid pharmaceutical formulation containing between 025% and 0.25% mol / mole of free macrocyclic chelate, preferably a macrocyclic chelate, preferably DOTA, NOTA , DOTAGA, DO3A, BT-DO3A, HP-DO3A and PCTA, preferably DOTA, wherein the method comprises the following sequential steps: b) First, a complex of a macrocyclic chelate compound and a lanthanide; Second, preparing a liquid pharmaceutical composition containing a free macrocyclic chelate compound and / or a free lanthanide; c) free large amount in the pharmaceutical preparation obtained in step b) Step measuring the concentration C ch 1 and / or concentration C lan 1 free lanthanide Jo chelate compound; d) wherein, C t ch 1 is at a target concentration of free macrocyclic chelate in the final liquid pharmaceutical formulation Adjusting C ch 1 and / or C lan 1 such that C ch 1 = C t ch 1 and C lan 1 = 0 are obtained. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11400172-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017535553-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018538358-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016117778-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10576169-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016521275-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013514311-A |
| priorityDate | 2008-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.