http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011513728-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A90-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57488 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6848 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G16C20-70 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate | 2009-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2011513728-A |
| titleOfInvention | Selection of head and neck cancer patients for treatment with drugs targeting the EGFR pathway |
| abstract | By means of mass spectral data analysis and classification algorithms, patients with head and neck squamous cell carcinoma (HNSCC) were treated with small molecule epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) and monoclonal antibody EGFR inhibitor. It is possible to determine whether it is likely to benefit from drugs that target the epidermal growth factor receptor pathway. The method comprises: a) obtaining a mass spectrum from a blood-based sample of a patient; b) performing one or more predefined pretreatment steps on the mass spectrum obtained in step a); c) step b Determining the integrated intensity value of the selected feature in the spectrum in one or more predefined m / z ranges after performing the pretreatment step on the mass spectrum of Step c using a training set comprising a class-labeled spectrum created from blood-based samples from other patients to identify whether the patient is likely to benefit or not. Using the numerical value obtained in step) for the classification algorithm. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2013520681-A |
| priorityDate | 2009-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.