| abstract |
The present invention relates to pharmaceutical compositions and methods for making such compositions, wherein the composition comprises a plurality of TPR particles and RR particles: each TPR particle comprises a core coated with a TPR layer; Includes a weakly basic sparingly soluble drug and a pharmaceutically acceptable organic acid separated from each other by an SR layer; each RR particle includes a weakly basic sparingly soluble drug, and United States Pharmacopoeia (USP) ) Elution test using the elution method (equipment 2-paddle, 50 RPM, and two-step elution medium at 37 ° C. (first tested in 0.1 N HCl for 2 hours, then in pH 6.8 buffer) Release at least about 80 wt.% Of the weakly basic, poorly soluble drug in about 5 minutes. [Selection] Figure 6 |