abstract |
The present invention relates to a method of increasing blood brain barrier permeability in a subject. The method includes selecting a subject that may benefit from increased blood brain barrier permeability and subjecting the selected subject to treatment. This treatment increases adenosine levels and / or bioavailability, modulates adenosine receptors, and / or CD73 levels under conditions effective to increase blood brain barrier permeability in said subject. And / or increase activity. Methods of reducing blood brain barrier permeability in a subject, methods of treating a subject for central nervous system disorders or conditions, methods of screening for compounds effective to increase blood brain barrier permeability, and agents Is also disclosed. |