abstract |
The present invention provides a novel substance in formula (I) wherein Het is a heterocycle optionally substituted by one or more groups R1 or R′1; R is from the group comprising formula (II) R1 and / or R′1 is selected from H, halogen, CF 3 , nitro, cyano, alkyl, hydroxyl, mercapto, amino, alkylamino, dialkylamino, alkoxy, phenylalkoxy, alkylthio, or free or alkyl esterified carboxy, carboxamide, CO-NH (alkyl), CON (alkyl) 2, NH-CO- alkyl, sulfonamide, NH-SO 2 - alkyl, S (O) 2 -NH-alkyl or S (O 2 ) -N (alkyl) is selected from the 2 group; any of these groups may be substituted; W1 W2 and W3 are independently a CH or N; X is O, S, NR2, C ( O), be a S (O) or S (O) 2; Z is an optionally substituted H, Hal, -O-R2 or -NH-R2, wherein R2 is H, alkyl, cycloalkyl or heterocyclic alkyl. These substances are all isomeric forms used as drugs and salts of the substances. |