| abstract |
The present invention relates to a novel 4-benzhydryloxy-tetraalkyl-piperidine derivative of formula (I) useful as a monoamine neurotransmitter reuptake inhibitor, any of its stereoisomers or any of its stereoisomers Or a N-oxide thereof, or a pharmaceutically acceptable salt thereof, wherein R a represents hydrogen or C 1-6 alkyl; R b and R c are each independently a phenyl group Wherein the phenyl group is optionally substituted with one or more substituents independently selected from the group consisting of halo, trifluoromethyl, trifluoromethoxy, cyano, C 1-6 alkoxy and methylenedioxo. R ′, R ″, R ′ ″ and R ″ ″ independently of one another represent C 1-6 alkyl, provided that the compound is 4-benzhydryloxy-1, 2,2, Not 6,6-pentamethyl-piperidine. In another aspect, the invention relates to the use of these compounds in therapy and pharmaceutical compositions comprising the compounds of the invention. |