| abstract |
Formula I: These compounds are useful for the inhibition of Raf kinase. For in vitro, in situ and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or related pathologies, compounds of formula I and stereoisomers, tautomers, prodrugs and pharmaceuticals thereof A method of using an acceptable salt is disclosed. In one aspect, the invention relates to compounds that are inhibitors of Raf kinases, particularly B-Raf inhibitors. Certain hyperproliferative disorders are characterized by overactivation of Raf kinase function, such as protein mutation or overexpression. Accordingly, the compounds of the present invention are useful in the treatment of hyperproliferative disorders such as cancer. |