| abstract |
A covalent complex of an α, α-disubstituted glycine ester and a modulator of target intracellular enzyme or receptor activity, wherein the ester group of the complex is one or more intracellular carboxylesterase enzymes And the α, α-disubstituted glycine ester is complexed with the modulator at a position away from the binding interface between the inhibitor and the target enzyme or receptor. The covalent complex enters the cell and the active acid hydrolyzate accumulates in the cell. [Selection figure] None |