| abstract |
The present invention relates to a compound of formula I or II or a pharmaceutically acceptable salt, ester or prodrug thereof. (I) or (II) relating to morphinan compounds useful as μ, δ and / or κ receptor opioid compounds and medicaments containing the same are used as mediators of analgesia, drug addiction, alcohol addiction, drug overdose, psychosis, bladder function Disorder, neurogenic bladder, interstitial cystitis, urinary incontinence, premature ejaculation, inflammatory pain, peripheral mediated and neuropathic pain, cough, pulmonary edema, diarrhea, heart disorder, cardiac defense, depression, and psychiatric, breathing May be useful in combating sex, diarrhea, irritable bowel syndrome and gastrointestinal disorders, immunomodulation and anti-tumor agents. |