| abstract |
The present invention relates to an oligopeptide compound containing a PCNA interaction motif or a nucleic acid molecule containing a sequence encoding the oligopeptide compound used in a therapeutic method, wherein the PCNA interaction motif is X 1 X 2 X 3 X 3 ′ X 1 ′ (SEQ ID NO: 1) wherein X 1 and X 1 ′ are independently selected from the group of basic amino acids, X 2 is a fat-soluble amino acid, and X 3 and X 3 ′ Are independently selected from the group of uncharged amino acids), the oligopeptide compound comprising: (i) the oligopeptide compound comprises at least one signal sequence; (ii) the PCNA interaction motif is [K / Oligopeptide compound comprising a PCNA interaction motif further characterized by at least one of R] -F- [LIV]-[LIV]-[K / R] (SEQ ID NO: 27) Or a nucleic acid molecule comprising a sequence encoding the oligopeptide compound. In particular, the treatment may be treatment of a disorder or condition in which it is desired to inhibit cell growth, such as treatment of a hyperproliferative disorder, or treatment involving cytostatic therapy, such as bone marrow removal. In certain embodiments, the compounds themselves may be used as cytostatics. In other embodiments of the invention, oligopeptide compounds containing such motifs may be used with cytostatics or radiation therapy. [Selection] Figure 1 |