abstract |
The present invention is directed to novel 2-amino-quinoline derivatives, pharmaceutical compositions containing them, and their use in the treatment of Alzheimer's disease (AD), mild cognitive impairment, senility and / or dementia. . The compounds of the present invention are inhibitors of β-secretase (also known as amyloid precursor protein β-site cleaving enzyme, BACE, BACE1, Asp2 or memapsin). |