| abstract |
The present invention is useful for therapeutic treatment of diseases associated with modulation or inhibition of 11β-HSD1 in mammals of formula (I), (Ia), (Ib), (Ic), (Id), (Ie) , (If), (Ig), (Ih), (Ii), a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof. The invention further relates to pharmaceutical compositions of the novel compounds and methods for their use in reducing or controlling the production of intracellular cortisol or in inhibiting the conversion of intracellular cortisone to cortisol. |