| abstract |
[Chemical 1] The present invention relates to a bifeprunox derivative of the formula (I) in which R 1 is one substituent selected from 3-OH, 4-OH, 3-OSO 3 H and 4-OSO 3 H; With respect to N-oxide or pharmaceutically acceptable salts, solvates or hydrates, it is a potent ligand for the dopamine D 2 receptor and exhibits a strong partial dopamine D 2 agonistic effect, more significant than bifeprunox Have a high percentage agonism. The compounds of the present invention, treatment of diseases and conditions dopamine D 2 operation effect the necessary dopamine D 2 receptor-mediated may be used in alleviating or preventing. |