| abstract |
Compounds having selective modulatory activity at α2B and / or α2C adrenergic receptor subtypes are of formula (1): (1) [Where: n = 1-4; X is C or N; R 1 to R 6 may be the same or different and are independently selected from the group consisting of: H, C 1-6 alkyl, OCH 3 , OH, F, Cl, Br, CH 2 OH, CH 2 N (R 7 ) 2 , C (O) R 8 , CH 2 CN, CF 3 ; Where R 7 is H or C 1-6 alkyl; R 8 is C 1-6 alkyl or aryl] Indicated by The compounds of formula (1) can be formulated into pharmaceutical compositions and used in methods of treating diseases or conditions mediated by α2 receptors. |