Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-475 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 |
filingDate |
2008-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2011-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2011507903-A |
titleOfInvention |
BMP variant with reduced sensitivity to Noggin |
abstract |
The present invention provides modified and very strong bone morphogenetic proteins. Specifically, the present invention relates to the observation that BMP-6 and BMP-9 are less sensitive to inhibition by Noggin, another member of the BMP subfamily of proteins. The invention features chimeric bone morphogenetic proteins in which the central portion of BMP-6 or BMP-9 replaces the central portion of another BMP subfamily protein, resulting in resistance to inhibition by Noggin or other Noggin-like antagonists And Other embodiments of modified BMPs, compositions and methods of use are also included. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012520066-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11597749-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021120400-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018506992-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018514590-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020517706-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10829518-B2 |
priorityDate |
2007-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |