| abstract |
The present invention is a compound having the general structural formula (VII) wherein L, R 1 , R 2 , R 3 , R 4 and R 5 are selected independently from each other and are as defined herein. Provided are compounds of (VII) and their 11-keto analogs, and pharmaceutically acceptable salts, solvates, esters, prodrugs, tautomers and isomers of said compounds and said 11-keto analogs . Also provided are pharmaceutical compositions, methods of manufacture, and methods of using the compounds in the treatment and prevention of a wide range of immune, autoimmune and inflammatory diseases and conditions. The novel compounds of the present invention have useful pharmacological activity as well as unexpectedly low systemic activity. Thus, the compounds of the present invention represent a safer alternative to the known glucocorticoids with poor side effect profiles. |