| abstract |
3-amino-3-cyclobutylmethyl-2-hydroxypropionamide of formula I Alternatively, a method of preparing a salt thereof comprises preparing a compound of formula VI as described herein in a solution comprising mostly dimethyl sulfoxide (DMSO), followed by an intermediate compound of formula VII as described herein. This compound is converted directly to a compound of formula VIII as described herein without treatment or isolation. Another aspect of the invention is a (1R, 2S, 5S) -3-azabicyclo [3,1,0] hexane-2-carboxamide of formula Z, N- [3-amino-1- (cyclobutylmethyl)- 2,3-dioxopropyl] -3-[(2S) -2-[[[1,1-dimethylethyl) amino] carbonylamino] -3,3-dimethyl-1-oxobutyl] -6,6-dimethyl Or it is a novel preparation method of the salt. |