| abstract |
The present invention generally relates to the field of therapeutic compounds, more specifically to the specific 3-substituted-4-dihydro-imidazo [5,1-d] [1,2,3,5] tetrazine-8-carboxylic acid amides. (Collectively referred to herein as 3TM compounds). The present invention also includes pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions both in vitro and in vivo in the treatment of proliferative disorders, such as cancer, to inhibit cell proliferation and the use of such compounds. It relates to a preparation method. |