| abstract |
The compounds of formula (I) have antibacterial activity: [Wherein m is 0 or 1; Q is hydrogen or cyclopropyl; Alk is ether (—O—), thioether (—S—) or amino (—NR) — (where R is A divalent C 1 -C 6 alkylene, alkenylene or alkynylene group which may contain a bond (which may be hydrogen, —CN or C 1 -C 3 alkyl) and may be optionally substituted; -C (= O) NR 6 -or -C (= O) O- (where R 6 is hydrogen, optionally substituted C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl a is); Z 1 is -N = or -CH =; Z 2 is -N = or -C (R 1) = a and; R 1 is hydrogen, methyl, ethyl , Ethenyl, ethynyl, methoxy, mercapto, mercaptomethyl, halo, fully or partially fluorinated (C 1 -C 2 ) alkyl, (C 1 -C 2 ) alkoxy or (C 1 -C 2 ) alkylthio , Nitro or nitrile (-CN) R 2 is a group Q 1- [Alk 1 ] q -Q 2- (where q is 0 or 1; Alk 1 is ether (—O—), thioether (—S—) or amino (—NR) — A divalent linear or branched C 1 -C 6 alkylene, C 2 -C 6 , which may contain an intermediate or terminal bond and may be optionally substituted An alkenylene or C 2 -C 6 alkynylene group; Q 2 is a divalent monocyclic carbocyclic or heterocyclic group having 5 or 6 ring atoms and optionally substituted Or a divalent bicyclic carbocyclic or heterocyclic group having 9 or 10 ring atoms and optionally substituted; Q 1 is hydrogen, optional Or a carbocyclic group or heterocyclic group having 3 to 7 ring atoms and optionally substituted) Is]. [Selection figure] None |