| abstract |
Therapeutically active 2- [4- (3- and 2- (fluorobenzyloxy) benzylamino) propanamide, and their salts with pharmaceutically acceptable acids in high purity, in particular the dibenzyl derivative impurity content Process for producing less than 0.03%, preferably less than 0.01% by weight. In this method, an organic solvent selected from C 1 -C 5 lower alkanols is saturated during the substantial part of the reduction reaction process, in which the Schiff base dissolves in the organic solvent and becomes saturated. Using the appropriate amount to allow, the Schiff base intermediate 2- [4- (3- and 2-fluorobenzyloxy) benzylideneamino] propanamide is obtained from sodium borohydride and potassium borohydride in an organic solvent. It is carried out by reduction with a selected reducing agent. |