abstract |
The present invention relates to novel methods and products for assessing the physiological state of a subject. More particularly, the present invention measures the level of antibodies to specific abnormal protein domains in a sample of a subject, or the presence or number of immune cells having a TCR specific for such abnormal protein domains, It relates to a method for assessing the presence, risk or stage of cancer in a subject. The present invention is also suitable for assessing a subject's responsiveness to treatment, as well as screening candidate drugs and designing new therapies. The present invention can be used in any mammalian subject, particularly a human subject. |