| abstract |
The present invention relates to a replication-deficient simian adenovirus vector C7 that encodes a protein comprising CS protein from Plasmodium falciparum or a fragment thereof (eg, those shown in SEQ ID NO: 1 or SEQ ID NO: 3). The present invention also relates to a method for producing the viral vector and the use of the viral vector in the treatment / prevention of malaria infection. Also described are compositions, vaccines and kits comprising the viral vectors. In one embodiment, the present invention uses a synthetic C7 viral vector. The C7 viral vectors of the invention can be co-administered or co-formulated with a malaria antigen such as RTS, S, optionally in the presence of an adjuvant such as 3D-MPL and / or an saponin (eg QS21). [Selection] Figure 16 |