| abstract |
The present invention relates to the structure L 100 -linker-L 100 , wherein L 100 is a lipid, lipophilic substance, alkyl, alkenyl, or alkynyl, and L 101 is a ligand or —CH 2 CH 2 (OCH 2 CH 2) p O (CH 2) q CH 2 - is a ligand, p is 1 to 1000, and q provides targeting lipids is 1 to 20).. Furthermore, the present invention provides compositions and methods for delivering therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that efficiently encapsulate nucleic acids and efficiently deliver the encapsulated nucleic acids to cells in vivo. |