http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011504361-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate | 2008-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2011504361-A |
| titleOfInvention | Peptides specific for hepatocellular carcinoma cells and their applications |
| abstract | Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer death worldwide. New therapeutic strategies derived from increased knowledge about molecular oncology are constantly being developed to treat this disease. Here we used phage display to identify new peptides that contain specific binding to HCC cells (SP94). In vitro, phage clone PC94 binds to the HCC cell line. In vivo, PC94 was a SCID mouse carrying a human HCC xenograft that specifically hometed to tumor tissue but did not home to normal internal organs. The homing ability could be competitively inhibited by the synthetic peptide, SP94. PC94 was localized in tumor tissue but could not be detected in SP94 competing tumor tissue or normal organs. Furthermore, PC94 recognized tumor tissue with a positive rate of 61.3% (19/31) in surgical specimens from HCC patients, but not non-tumor tissue. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020089387-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7149450-B2 |
| priorityDate | 2007-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 250.