| abstract |
The present invention relates to formulas (I), (Ia), (Ib), (Ic), (Id), (I) useful for therapeutic treatment of diseases associated with modulation or inhibition of 11β-HSD1 in mammals. Ie), (If), (Ig), (Ih), (Ij), (Ik), (II 1-3 ), (Im 1-3 ), (In 1-3 ), (Io 1-2 ) , (Ip 1-6 ), (Iq 1-6 ), (Ir 1-6 ) and (Is 1-2 ), a pharmaceutically acceptable salt thereof, and a pharmaceutical composition thereof. The invention further relates to pharmaceutical compositions of said novel compounds and methods for their use for use in reducing or controlling the production of cortisol in cells or inhibiting the conversion of cortisone to cortisol in cells. |